An MDA-supported research team has identified compounds that may prevent nerve-cell loss caused by dysregulation of a critical cell survival mechanism
- An MDA-supported research team has identified a series of compounds that appear to work alone and in combination to protect the nerve cells that are lost in amyotrophic lateral sclerosis (ALS).
- Worm and zebrafish models of ALS that were treated with the compounds showed less neurodegeneration and less paralysis than untreated animals.
- The compounds all target various pathways involved in the endoplasmic reticulum (ER) stress response, a critical cell survival mechanism that works to decrease nerve cell stress
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